氨基末端B型脑钠肽前体与心力衰竭的相关性研究被引量：2

Study on Correlation between N-terminal Pro-brain Natriuretic Peptide and Heart Failure

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摘要目的探讨血浆中N末端B型脑钠肽前体(NT-proBNP)水平改变对心力衰竭(HF)的诊断意义。方法对209例临床HF患者和40例健康人群同时进行血浆NT-proBNP、血清CTn1(金标法)和超声心动图等检测,并进行统计学分析。结果 HF患者血浆NT-proBNP水平高于健康人群组。其中Ⅲ、Ⅳ级HF患者金标法测定CTn1均为阳性且血浆NT-proBNP随病情的加重而逐渐升高。结论血浆NT-proBNP对心力衰竭患者有很好的诊断价值。 Objective To explore the significance of changes of plasma N - terminal pro - 15 - type natriuretic peptide （NT- proBNP） concentration in diagnosis of heart failure （HF）. Methods The levels of plasma NT- proBNP and serum CTnl were simultaneously detected and echocardiography was conducted in 209 patients with HF and 40 healthy individuals. The results were statistically analyzed. Results The level of plasma NT - proBNP in patients with HF was higher than that in healthy group. Serum CTnl which was detected by gold standard method in the patients with grade Ⅲ or Ⅳ HF was positive, and the levels of plasma NT- proBNP increased gradually along with the aggravating condition. Conclusions Plasma NT - proBNP has a good diagnostic value for patients with HF.

作者陈朝晖周铁明

机构地区湖南中医药大学第二附属医院

出处《实用预防医学》 CAS 2012年第1期112-113,共2页 Practical Preventive Medicine

关键词心力衰竭血清NT—proBNP 相关性 Heart failure Plasma NT-proBNP Correlation

分类号 R541.4 [医药卫生—心血管疾病]

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