妊娠合并阻塞性睡眠呼吸暂停低通气综合征患者内脂素和巨噬细胞移动抑制因子的检测意义

Serum visfatin and macrophage migration inhibitory factor levels in pregnant women with obstructive sleep apnea hypopnea syndrome

探讨妊娠合并阻塞性睡眠呼吸暂停低通气综合征（OSAHS）与血清内脂素和巨噬细胞移动抑制因子（MIF）的相关性及其意义。选择妊娠合并OSAHS患者102例（分成轻度、中度和重度）和正常妊娠组36例，采用ELISA检测血清内脂素和MIF含量。OSAHS合并高血压组睡眠呼吸暂停低通气指数（AHI）、平均动脉压（MAP）、内脂素和MIF含量明显高于单纯OSAHS组（均P〈0．01），单纯OSAHS组明显高于正常妊娠组（均P〈0．01）；同时重度OSAHS患者的内脂素和MIF含量明显高于中度OSAHS，中度明显高于轻度患者，差异有统计学意义（均P〈0．01）。妊娠合并OSAHS患者病情与内脂素、MIF水平密切相关。

One hundred and two pregnant women with obstructive sleep apnea hypopnea syndrome （OSAHS） and 36 healthy pregnant women （ control group ） were enrolled in the study. Serum visfatin and macrophage migration inhibitory factor （MIF） levels were detected by enzyme linked immunosorbent assay （ELISA）. The results showed that apnea-hypopnea index （AHI）, mean arterial pressure （MAP）, serum visfatin and MIF levels in pregnant women with OSAHS were significantly higher than those of controls （ all P〈0.01 ）. In pregnant women, AHI, serum visfatin and MIF levels of patients having OSAHS with hypertension were significantly higher than those of patients with OSAHS only （ all P 〈 0. 01 ）. Patients with severe OSAHS had higher levels of visfatin and MIF than those with moderate OSAHS, and patients with moderate OSAHS had higher visfatin and MIF levels than those with mild OSAHS （P 〈 0. 01 ）. The AHI was significantly correlated with MAP, serum levels of MIF and visfatin （ r = 0. 75,0. 71,0. 68, respectively, all P 〈 0. 01 ） in pregnant women with OSAHS.