奥曲肽对洛哌丁胺治疗失败的化疗性腹泻的临床疗效观察

Clinical curative effects of Octreotide on chemotherapy-induced diarrhea refractory to Loperamide

目的探讨奥曲肽对洛哌丁胺治疗失败的化疗相关性腹泻(CID)的临床疗效和安全性。方法对48例洛哌丁胺治疗失败的Ⅲ级CID中晚期肿瘤患者,皮下注射醋酸奥曲肽0.15 mg,3次/d,每隔24 h观察腹泻治疗效果。结果所有患者均行客观疗效及安全性评价,总有效率为79.2%(38/48),平均有效缓解时间为2.8 d:其中30例(62.5%)在前3 d评价为有效,8例(16.7%)在第4、5 d评价为有效,10例(20.8%)评价为无效。2例(4.2%)出现轻度恶心,1例(2.1%)出现局部注射部位疼痛。结论奥曲肽治疗洛哌丁胺无效的CID是一种有效、安全的方法,值得在临床推广应用。

Objective To discuss the clinical curative effects and safety of Octreotide in the management of chemotherapy - induced diarrhea（CID） refractory to Loperamide. Methods Forty eight patients at the middle and advanced stage of tumor with grade m CID refractory to Loperamide were subcutaneously injected with 0.15 mg Octreotide acetate 3 times per day. After every 24 h,the curative effects on diarrhea were observed. Results All the patients received the evaluation of objective curative effects and safety. The total effective rate was 79.2% （ 38/48 ） and the average effective release time was 2.8 d. Among these patients, the curative effects in 30 cases （62.5%） were evaluated as valid in the first 3 days, and the effects in 8 cases （ 16.7% ） were evaluated as valid on day 4 to 5. The effects in 10 cases（20.8% ）were evaluated as invalid. Mild nausea occurred in 2 cases （4.2%）, and pain occurred in part of the injection site in 1 case（2.1% ）. Conclusion It is an effective and safe way to use Octreotide in the treatment of CID refractory to Loperamide.