2001—2010年临床分离阴沟肠杆菌的分布及耐药性变迁

Distribution and changing pattern of antibiotic resistance in Enterobacter cloacae isolates during year 2001—2010

目的了解广西医科大学第三附属医院临床分离阴沟肠杆菌的分布和耐药性的变迁。方法对该院2001—2010年临床分离的阴沟肠杆菌,进行细菌鉴定和药敏试验。结果 2001—2010年共分离出930株阴沟肠杆菌,其中分离于痰标本498株、咽拭子32株、尿标本162株、血液标本30株、分泌物155株、其他体液3株。药敏试验结果显示阴沟肠杆菌对氨苄西林和头孢唑林的耐药率最高;对哌拉西林-他唑巴坦耐药率较低;对亚胺培南耐药率最低,对氟喹诺酮类的耐药率上升较快。结论阴沟肠杆菌的耐药情况日趋严重,并出现了对碳青霉烯类抗生素不敏感株,应采取相应的控制措施以遏制耐药株的增长。

Objective To investigate the distribution and changing pattern of antibiotic resistance in Enterobacter cloacae isolates in the Third Affiliated Hospital of Guangxi University of Medical Sciences. Methods A total of 930 clinical strains of E. cloacae were collected from 2001 to 2010. Antimicrobial susceptibility testing was performed for these strains. Results The source of these isolates included sputum （498）, pharyngeal swab （32）, urine （162）, blood （30）, secretions （155）, and body fluid （53）. The percentage of E. cloacae resistant to ampieillin and cefazolin was the highest, but relatively lower to piperaeillin-tazobactam. These strains showed the lowest resistance rate to imipenem. The resistance rate to fluoroquinolone was rising quickly. Conclusions The antimicrobial resistance of E. cloacae was serious. Especially, carbapenems-resistant isolate was identified. Effective control measures should be taken to curb the increase of such resistant strains.