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肿瘤坏死因子转化酶(TACE)最新研究进展

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摘要 1 TNF-α裂解酶的发现TNF-α前体(TM-TNF-α)需要加工去除氨端76个氨基酸残基,才能成为游离型TNF-α(S-TNF-α),进入循环系统。80年代末,人们认为这一加工过程依赖于丝氨酸蛋白水解酶;到了90年代,
作者 孙震 喻明霞
出处 《中国免疫学杂志》 CAS CSCD 北大核心 2011年第12期1135-1138,共4页 Chinese Journal of Immunology
基金 2008年中央高校基本科研业务费专项基金(No.3082009) 2008年武汉大学中南医院青年科研基金(No.22#)和武汉大学大学生科研项目(No.S2009402)资助
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参考文献36

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二级参考文献11

  • 1Black RA, Rauch CT, Kozlosky CJ, et al. A metalloproteinase disintegrin that releases tumor-necrosis factor-alpha from cells. Nature, 1997, 385(6618) : 729-733.
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  • 7Loechel F, Gilpin BJ, Engvall E, et al. Human ADAM 12 (meltrin alpha) is an active metalloprotease. J Biol Chem, 1998, 273 (27) : 16993-16997.
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