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肿瘤坏死因子转化酶(TACE)最新研究进展

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摘要 1 TNF-α裂解酶的发现TNF-α前体（TM-TNF-α）需要加工去除氨端76个氨基酸残基,才能成为游离型TNF-α（S-TNF-α）,进入循环系统。80年代末,人们认为这一加工过程依赖于丝氨酸蛋白水解酶;到了90年代,
作者 孙震 喻明霞
机构地区 武汉大学中南医院检验科&基因检测中心
出处 《中国免疫学杂志》 CAS CSCD 北大核心 2011年第12期1135-1138,共4页 Chinese Journal of Immunology
基金 2008年中央高校基本科研业务费专项基金(No.3082009) 2008年武汉大学中南医院青年科研基金(No.22#)和武汉大学大学生科研项目(No.S2009402)资助
关键词 肿瘤坏死因子 TM-TNF-Α 转化酶 加工过程 氨基酸残基 蛋白水解酶 循环系统 裂解酶
分类号 R392.11 [医药卫生—免疫学]
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参考文献36

  • 1Black R A, Rauch C T, Kozlosky C Jet al. A metalloproteinase disintegrin that releases tumour-necrosis factor-alpha from cells [ J ]. Nature, 1997 ; 385(6618) :729-733.
  • 2Moss M L, Jin S L, Milla M E et al. Cloning of a disintegrin metallopro- teinase that processes precursor tumour-necmsis factor-alpha [ J ]. Nature,.1997; 385 (6618) : 733-736.
  • 3Srour N, Lebel A, McMahon Set al. TACE/ADAM-17 maturation and ac- tivation of sheddase activity require proprotein convertase activity [ J ]. FEBS Lett, 2003 ; 554 (3) : 275-283.
  • 4Reddy P, Slack J L, Davis R et al. Functional analysis of the domain structure of tumor necrosis factor-alpha conveing enzyme [ J ]. J Biol Chem,2000;275(19) :14608-14614.
  • 5Sisto M,Lisi S,Lofrumento D D et al. TNF-a blocker drugs modulate hu- man TNF-a-converting enzyme pro-domain shedding induced by autoanti- bodies[ J]. Immunobiology, 2010; 215 ( 11 ) : 874-883.
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  • 8Yin J, Yu F S. ERK1V2 mediate wounding-and G-protein-coupled receptor ligands-induced EGFR activation via regulating ADAM17 and HB-EGF shedding[ J]. Invest Ophthalmol Vis Sci, 2009; 50( 1 ) : 132-139.
  • 9Canault M, Tellier E, Bonardo B et al. FHL2 interacts with both ADAM- 17 and the cyteskeleton and regulates ADAM-17 localization and activity [J] .J Cell Physiol,2006;208(2):363-372.
  • 10Nishi E, Hiraoka Y, Yoshida K et al. Nardilysin enhances ectodomain shedding of heparin-binding epidermal growth factor-like growth factor through activation of tumor necrosis factor-alpha-converting enzyme[ J]. J Biol Chem,2006;281 (41) :31164-31172.

二级参考文献11

  • 1Black RA, Rauch CT, Kozlosky CJ, et al. A metalloproteinase disintegrin that releases tumor-necrosis factor-alpha from cells. Nature, 1997, 385(6618) : 729-733.
  • 2Moss ML, Jin SL, Milla ME, et al. Cloning of a disintegrin metalloprotease that processes tumor-necrosis factor-alpha. Nature, 1997, 385 (6618 ) : 733-736.
  • 3Lichtenthaler SF, Haass C. Amyloid at the cutting edge: activation of alpha-secretase prevents amyloidogenesis in an Alzheimer disease mouse model. J Clin Invest, 2004, 113 (10): 1384- 1387.
  • 4Anders A, Gilbert S, Garten W, et al. Regulation of the alphasecretase ADAM10 by its prodomain and proprotein convertases. FASEB J, 2001, 15(10) : 1837-1839.
  • 5Hansen HP, Dietrich S, Kisseleva T, et al. CD30 shedding from Karpas 299 lymphoma cells is mediated by TNF-alpha-converting enzyme. J Immunol, 2000, 165(12) : 6703-6709.
  • 6Amin AR. Regulation of tumor necrosis factor-alpha and tumor necrosis factor converting enzyme in human osteoarthritis. Osecoarhritis Cartialge, 1999, 7(4) : 392-394.
  • 7Loechel F, Gilpin BJ, Engvall E, et al. Human ADAM 12 (meltrin alpha) is an active metalloprotease. J Biol Chem, 1998, 273 (27) : 16993-16997.
  • 8Stour N, Lebel A, McMabon S, et al. TACE/ADAM-17 maturation and activation of sheddase activity require proprotein convertase activity. FEBS Lett, 2003, 554 (3) : 275-283.
  • 9Howard L, Maciewicz RA, Blobel CP. Cloning and characterization of ADAM28: evidence for autocatalytic pro-domain removal and for cell surface localization of mature ADAM28. Biochem J, 2000, 348(Pt 1) : 21-27.
  • 10Loechel F, Overgaard MT, Oxvig C, et al. Regulation of human ADAM 12 protease by the prodomain. Evidence for a functional cysteine switch. J Biol Chem, 1999, 274(19) : 13427-13433.
中国免疫学杂志
2011年 第12期

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