赴非洲维和官兵多种疫苗应急接种的免疫效果

EFFECT OF EMERGENCY INOCULATION WITH FOUR KINDS OF VACCINE ON SOLDIERS TO AFRICA FOR PEACE-KEEPING

目的了解维和部队官兵在短时间内完成4种疫苗接种后的安全性及血清抗体水平动态,为指导部队应急条件下疫苗的接种提供依据。方法选取赴非洲我军维和官兵93人(男性)接种肾综合征出血热疫苗、A+C群脑膜炎球菌多糖疫苗、伤寒Vi多糖疫苗、乙型脑炎减毒活疫苗,分别在接种疫苗前、后进行血清特异IgG抗体检测。结果在接种疫苗前,肾综合征出血热、A+C群脑膜炎球菌、伤寒、乙型脑炎血清抗体阳性率分别为10.7%,52.7%,7.5%,22.6%;接种疫苗后30 d内血清抗体阳性率分别提升为36.6%,95.7%,25.8%,40.9%;接种疫苗后300d内,血清抗体阳性率仍保持在较高水平。结论在短时间内接种4种疫苗,血清抗体阳性率有明显提高。

Objective To observe the safety, serological efficacy and immunization effect of four kinds of vaccine on soldiers to Africa for peace-keeping, so as to provide the basis for directing vaccination in an emergency. Methods ELISA was used to detect serum IgG antibodies of 4 kinds of vaccine： hemorrhagic fever with renal syndrome （HFRS） vaccine,group A ＋ C meningococcal pelysaccharide vaccine, typhoid Vi polysaccharide vaccine, Japanese encephalitis vaccine （live）. Results The positive rate of hemorrhagic fever with renal syndrome vaccine, group A ＋ C meningococcal polysaccharide vaccine, typhoid Vi pelysaccharide vaccine, and Japanese encephalitis vaccine （live） on the 30 th day after inoculation （ 36.56%, 94.62%, 53.76%, and 59.14% respectively ） Were higher than those before vaccination （ 10.75 %, 52.68 %, 7.52%, and 22.58 % ）, （ P 〈 0.01 ） . The antibody positive rate remained at high level within 300 days. Conclusion The serum antibody positive rate of 4 kinds of vaccine in peace-keeping soldiers was significantly increased after inoculation in a short time.