乳腺癌术后应用托瑞米芬对子宫内膜影响及相关因素分析

目的探讨乳腺癌术后患者应用托瑞米芬治疗对自身内分泌,子宫内膜的影响。方法 203例乳腺癌患者术后应用托瑞米芬,比较服药前及服药后每6个月血清雌激素、孕激素水平、子宫内膜厚度(B超),子宫内膜病变发生率。结果服用托瑞米芬后每6个月雌激素水平较服药前明显降低(P<0.05),孕激素水平明显升高(P<0.05)。宫内膜厚度未见明显变化(P>0.05)。子宫内膜病变发病率无明显差异(P>0.05)。结论乳腺癌患者术后长期应用托瑞米芬,降低了雌激素水平,提高了孕激素水平,无明显增加子宫内膜厚度,未见明显增加子宫内膜病变发生率。

Objective To investigate impact of long-term application of toremifene in breast cancer patients on their endocrine and endometrium.Methods 201 postoperative patients of breast cancer were treated with toremifene.To compare the serum levels of estrogen and progesterone levels,endometrial thickness（B Ultra） before and after treatment every 6 months.Results Every 6 months,level of estrogen after taking toremifene significantly decreased compared with before taking（P0.05）,while progesterone levels were significantly higher（P0.05）.No significant changes in endometrial thickness（P0.05） or rates of pathological changes of endometrium.Conclusion Long-term application of toremifene in breast cancer patients would decrease level of estrogen and increase progesterone levels but no significant changes in endometrial thickness or pathology transforms.