氯吡格雷联合前列地尔治疗急性脑梗死的临床疗效观察

目的评估氯吡格雷联合前列地尔治疗急性脑梗死的临床疗效。方法 60例急性脑梗死患者采用随机数字表法随机分为治疗组和对照组各30例,治疗组采用氯吡格雷联合前列地尔,对照组采用常规阿司匹林治疗。治疗14d后观察神经功能评分和相关的实验室生化指标。结果治疗组30例均完成随访,对照组29例完成随访。国国立卫生研究院卒中量表评分治疗组平均得分(2.01±0.98),对照组平均得分(4.87±1.52),两组比较差异有统计学意义(P=0.001)。治疗后两组比较,IL-6、TNF-α、C反应蛋白、血小板采集率、组织纤溶酶原激活物、均发生明显改变,差异有统计学意义。结论氯吡格雷联合前列地尔治疗急性脑梗死近期疗效较好,安全性好。但仍需要大样本临床试验进一步证实其远期疗效。

Objective To evaluate the effect of clopidogrel and alprostadil for acute cerebral infarction.Methods Sixty patients with acute cerebral infarction using random number table,were randomly divided into treatment group（30 cases）and control group（30 cases）,treatment group were treated with clopidogrel alprostadil,the control group treated with routine aspirin therapy.After 14 days,the NIHSS score and the biochemical index of two groups were evaluated.Results Thirty cases completed follow-up in experimental group,29 patients completed follow-up in control group.NIHSS score in treatment group average score were（2.01 ± 0.98）,control group were（4.87 ± 1.52）,the difference was statistically significant（P=0.001）.After treatment,the IL-6,TNF-α,C-reactive protein,platelet collection rate,tissue plasminogen activator,significant changes had occurred,the difference was statistically significant.Conclusion Clopidogrel combined alprostadil for acute cerebral infarction is better than routine treatment,but still require large clinical trials to confirm its long-term effect further.