帕瑞昔布钠与氟比洛芬酯对肛肠和直肠手术后镇痛效果的比较

Comparison of the analgesic effect of parecoxib and flurbiprofen in the postoperative pain after anal and rectal surgery

目的 比较肛肠和直肠手术后帕瑞昔布钠与氟比洛芬酯的镇痛效果.方法 肛肠和直肠手术患者40例,随机分为两组,A组（n=20）手术结束前静脉注射帕瑞昔布40 mg,B组（n=20）手术结束前静脉注射氟比洛芬酯1 mg/kg,采用VAS评分观察术后镇痛效果与不良反应.结果 A组较B组VAS评分低（P〈0.05）,B组恶心、呕吐较多.结论 肛肠和直肠手术后单次静脉注射帕瑞昔布与氟比洛芬酯均有镇痛效果,前者能明显减轻术后疼痛且不良反应较少.

Objective To compare the analgesic effect of parecoxib and flurbiprofen in the postoperative pain after anal and rectal surgery. Method Forty patients undergoing anal and rectal surgery were randomly divided into two groups. The patients were administered intravenously parecoxib sodium（group A,n =20） or flurbiprofen（group B,n=20） at 20 minutes before the end of the opera- tion in parecoxib group and in the flurbiprofen group respectively. Visual analog scale（VAS）and adverse reactions after the operation were recorded. Results The VAS in group A was lower than that in group B（P^0.05）, the adverse reactions were obvious in group B. Conclusion Both pare- coxib and flurbiprofen can effectively offer analgesia for patients after anal or rectal surgery, but parecoxib is better and less adverse reactions.