恩替卡韦治疗乙型肝炎患者血清铁蛋白的检测与临床意义

Significance of serum ferritin in entecavir-treated chronic hepatitis B patients

目的:检测慢性乙型肝炎患者血清铁蛋白(SF)的水平及恩替卡韦抗病毒治疗前后的变化。方法:采用化学发光法检测102例慢性乙型肝炎患者SF水平,并检测ALT、HBV DNA、基因型等指标。结果:轻度、中度至重度患者SF水平依次递增,均高于健康对照组,SF与ALT水平呈正相关,不同基因型之间SF水平差异无统计学意义(P>0.05)。抗病毒治疗48周后,ALT复常组及HBV DNA阴性组患者SF水平均明显下降。结论:检测SF水平可以在一定程度上反映肝脏炎性反应程度。定期监测SF的变化,对判断恩替卡韦抗病毒疗效及疾病预后有一定意义。

Objective To investigate the serum ferritin（SF） in chronic hepatitis B patients and the changes after entacarir treatment.Method The SF in 102 patients with chronic hepatitis B and 38 healthy subjects were tested by chemiluminescence,parameters of liver function,HBV-DNA and genotype were detected in the same time.Results Compared with the healthy subjects,the levels of SF were gradually increased in the mild,moderate and severe types of chronic hepatitis patients.The levels of SF in hepatitis patients before treatment correlated well with ALT（r=0.618,P〈0.01）.The SF were not related to the genotype（P〈0.05）.The levels of SF in patients with normalized serum ALT and those negative for HBV-DNA were significantly decreased after treatment of 48 weeks.Conclusion The findings indicate that SF may reflect the degree of inflammation in the liver.It may be helpful to judge the antivirus effect and prognosis in entacarir-treated patients by monitoring the changes of SF.