保护的3,6位支化葡萄三糖选择性合成

Selective synthesis of protected 3,6-branched trisaccharide

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摘要以2,3,4,6-四-O-苯甲酰-α-D-吡喃葡萄糖三氯乙酰亚胺酸酯为糖基供体,与不保护的烯丙基-α-D-吡喃葡萄糖苷为糖基受体进行一锅糖苷化法反应制得标题化合物。同时,对反应溶剂及配比进行了考察,目标产物及重要中间体的结构经MS、1HNMR、13CNMR及1H-1H COSY表征。 The glycosylation of protected 3,6-branched trisaceharide was one-pot synthesized from the donor of 2,3,4,6- tetra-O-benzyl-α-D-glueopyranosyl trichloroacetimidate with the aceeptor of unprotected allyl-α-D-glueopyranoside in a high yield and selectivity. The effects of solvents and molar ratio of substrates on the reaction selectivity were investigated. The structures of trisaccharide and important intermediates were confirmed by MS, 1HNMR, 13CNMR and 1H-1H COSY.

作者杨雷雷王军胡小丽杨晶朱玉亮

机构地区南京工业大学生物与制药工程学院江苏警官学院公安科技系

出处《化学试剂》 CAS CSCD 北大核心 2012年第1期74-78,共5页 Chemical Reagents

关键词三氯乙酰亚胺酸酯烯丙基-α-D-吡喃葡萄糖苷 3 6位支化葡萄糖糖苷化反应合成 trichloroacetimidate allyl a-D-glucopyranoside 3,6-branched glucan glycosylation reaction synthesis

分类号 O629.1 [理学—有机化学]

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1周俊,郭振楚.2-脱氧-2-氨基-β-D-吡喃葡萄糖氮苷的合成[J].合成化学,2008,16(2):186-188.

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保护的3,6位支化葡萄三糖选择性合成

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