摘要
以2-氨基苯甲腈为原料,DMF为反应试剂和溶剂,在苯磺酰氯的存在下高产率地合成了中间体亚胺啶的盐酸盐,该盐酸盐用NaOH溶液处理以后得到固态中间体亚胺啶,此中间体不须纯化,直接在乙酸中与乙醇胺或苯胺反应较高产率合成了6种标题化合物,并用IR、1HNMR和MS进行了表征。
The 2-amino-benzonitrile reacted with DMF and benzenesulfonyl chloride to give hydrochlorides of the inter- mediates, the intermediates obtained by neutralization of the hydrochlorides with sodium hydroxide solution,without purifi- cation,were directly reacted with ethanolamine or aniline in the acetic acid to from six title compounds in high yield. The structures were confirmed by IR,HNMR and MS.
出处
《化学试剂》
CAS
CSCD
北大核心
2012年第1期88-90,共3页
Chemical Reagents
关键词
2-氨基苯甲腈
4-取代氨基喹唑啉
合成
表征
2-amino-benzonitrile
4-substituted amino-quin-azolines
synthesis
characterization
