酒精性肝硬化患者血清甲状腺激素水平分析

Analysis of serum thyroid hormone levels in patients with alcoholic cirrhosis

目的探讨酒精性肝硬化患者血清甲状腺激素水平变化与临床特点。方法 87例肝硬化患者,其中酒精性肝硬化36例(酒精组)、乙肝肝硬化51例(乙肝组),对照组为健康志愿者11例。根据肝功能对酒精性肝硬化患者进行Child-pugh分级。采用放射免疫法检测患者甲状腺激素血清浓度。结果肝硬化组血清TT3、FT3、TT4和FT4水平均低于对照组(P均<0.01),酒精组亦低于乙肝组(P均<0.05)。酒精组随着肝功能分级升高,FT3和FT4逐渐降低。结论肝硬化患者存在明显的甲状腺激素水平异常,以酒精性肝硬化患者更为突出,甲状腺激素水平随肝功能损伤程度呈动态变化。

Objective To investigate the serum thyroid hormone levels and clinical characteristics in patients with alcoholic cirrhosis.Methods A total of 87 cases of cirrhosis,including alcoholic cirrhosis 36 cases（alcohol group）,liver cirrhosis 51 cases（hepatitis B group）,healthy volunteers 11 cases（control group）.According to liver function,patients with alcoholic cirrhosis were classified by Child-pugh classification,and detected the serum thyroid hormone concentrations by radioimmunoassay.Results Serum levels of TT3,FT3,TT4 and FT4 in cirrhosis groups were significantly lower than those in healthy control group（P0.01）,and the above index in hepatitis B group were lower than those in alcohol group（P0.01）.With the increase of liver function in alcohol cirrhosis group,FT3 and FT4 decreased gradually.Conclusion Cirrhotic patients with abnormal thyroid hormone levels,especially in patients with alcoholic cirrhosis,thyroid hormone levels showed the dynamic change with degree of liver function.