唐山地区震后卵巢癌发病率的病例对照研究

Case-control study on the ovarian cancer incidence after the earthquake in Tangshan area

①目的探讨唐山地区震后卵巢癌发病率与社会心理因素及环境因素的关系。②方法观察组入选病例为在唐山市妇幼保健院、唐山市工人医院、唐山市肿瘤医院、华北煤炭医学院附属医院经病理学确诊的新发女性卵巢癌患者。对照组选取病例为所在医院非肿瘤、非生殖内分泌系统疾病女性患者,使观察组及对照组的日常暴露一致。观察组及对照组入选病例均在唐山本地居住30年以上。应用条件Logistic回归模型分析各自因素与卵巢癌发病的关系。③结果观察组与对照组房屋倒塌情况比较,两者有显著性差异(P<0.05);在家庭成员伤亡情况比较中,伤亡人数两者相比有显著性差异(P<0.05);房屋完全倒塌同时家庭成员全部伤亡情况比较中,观察组与对照组相比具有显著性差异(P<0.05);观察组与对照组地震后居住新房次数及震后农药暴露史方面比较,差异具有统计学意义(P<0.05);多因素Logistic回归模型结果显示房屋倒塌、家庭成员伤亡、房屋倒塌家庭成员伤亡、居住新房次数及震后农药暴露史均是增加卵巢癌发病率的危险因素。④结论社会心理因素及环境状况可能是卵巢癌发生的危险因素;唐山地震可能增加当地卵巢癌的发病危险。

Objective The relation between Ovary cancer incidence and social psychology and environmental factors after the earthquake in Tangshan area. Methods Collected patients from Taugshan maternity hospitals, Tangshan gongren hospital, Tangshan Tumor hospital, pathology of female ovary cancer patients treated send. Contrast to choose the case is not tumor in these hospital, the women not of the endocrine system disease,make consistent between the case and contrast to the daily exposure. All cases and contrasts resident in tangshan local at least 30 years. The logistic regression model for each element analysis of the occurrence of relations with ovary cancer. Results A significani difference between two groups in comparison with houses collapsed （ P 〈 0.05 ）, family members of the casualties is a significant difference between the two groups （ P 〈 0.05 ） , the housing completely break down and the family members casualties has a significant difference between the two groups（ P 〈 0. 001 ） , there are significant difference between two groups in living in the new house after earthquake and pesticides exposure（ P 〈 0.01 ）. Many factors logistic regression model show that the houses have collapsed and family members of the casualties, and the exposure of pesticide increase the incidence of ovary cancer risk factors. Conclusion Social psychological factors and environmental conditions are the risk factors in ovary cancer ; Tangshan earthquake may increase the local ovary cancer risks.