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L-酒石酸托特罗定合成工艺改进

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摘要 反式肉桂酸与对甲苯酚脱水环合、单甲基化制得3-(2-甲氧基-5-甲氧苯基)-3-苯基丙酸,经(+)-α-苯乙胺拆分得到(R)-3-(2-甲氧基-5-甲氧苯基)-3-苯基丙酸,再经氯化、胺化、还原、去甲基制得(R)-托特罗定,最后与L-酒石酸成盐,得到抗尿失禁药L-酒石酸托特罗定,总收率21%。
作者 麻勇 王金桂
出处 《科技与企业》 2012年第2期194-194,共1页 Science-Technology Enterprise
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