闽东地区153例戊型肝炎临床与流行病学分析

Clinical and epidemiological analysis of 153 cases of hepatitis E in eastern Fujian area

目的了解闽东地区戊型肝炎近年来的流行病学特征及临床表现、治疗及预后情况,为该地区戊型肝炎的预防及临床诊治提供参考。方法对福建医科大学附属闽东医院近5年收治的153份戊型肝炎病例资料进行统计分析。结果本组患者153例,中老年患者85例(55.55%),男多于女,夏秋季发病最多为98例(64.05%),城镇与农村患者之比1.10∶1,重叠肝炎病毒感染17例(11.11%),无家庭聚集现象。所有病例均有不同程度的疲乏及肝功能异常,其中,黄疸型肝炎128例(83.66%)。治疗以卧床休息、清淡及富营养饮食为主,本组病例均好转及治愈出院,无1例转为慢性或死亡,重叠感染、年老及重症肝炎患者黄疸消退时间明显延长。结论戊型肝炎的发病及临床特点,与性别、年龄、居住环境、原有肝炎病毒慢性感染等因素有一定的关系。加强公共卫生管理和教育,培养良好的个人饮食和卫生习惯,是预防戊型肝炎的重要措施。

Objective To investigate the clinical and epidemiological features of hepatitis E and offer suggests to control this disease in eastern Fujian areas. Method The clinical data of 153 hospitalized patients with hepatitis E were analyzed and the clinical features were summarized. Results A total of 153 patients with hepatitis E began with fatigue and liver function test abnormality and most of patients had symptoms of jaundice （83.66%）. All of the patients were treated with bed rest, light and rich nutrition diet, and drugs for liver protection. The ALT level was decreased. Some cases of co-infected and old patients were not easy to cure. Conclusions The incidence and clinical characteristics of hepatitis E are related with various factors including sex, age, environment of residence, and immunity.Therefore,it is important to strengthen public health management and education and to cultivate good personal diet and health habits for preventing hepatitis E.