组织蛋白酶D在涎腺黏液表皮样癌中的表达

Significance of expression of Cathepsin-D in mucoepidermoid carcinoma of salivary gland

目的探讨组织蛋白酶D(Cath-D)在涎腺黏液表皮样癌中表达的意义。方法采用苏木素-伊红染色方法筛选典型病例与免疫组织化学方法分析21例黏液表皮样癌中Cath-D的表达。结果 Cath-D在正常涎腺组织的基底膜、腺管部位有弱阳性表达,在黏液表皮样癌中有强阳性表达,其强弱程度与病理分级存在相关性(r=0.54,P<0.01)。染色强度与染色面积评分之和与病理分级存在相关性(r=0.66,P<0.01)。在肿瘤浸润前沿表达显著。结论在涎腺黏液表皮样癌中Cath-D表达强弱程度与病理分级密切联系,癌症浸润前沿表达情况可以为临床治疗提供参考。

Objective To study the significance of expression of Cathepsin-D in mucoepidermoid carcinoma of salivary gland. Meth- ods 21 cases with mucoepidermoid carcinoma were determined by HE staining and the expression of Cathepsin-D was examined by immunohistochemistry method. The relationship between Cathepsin-D and histological type was analyzed. Results Statistical analysis showed that the expression level of paxillin was positively correlated with histological type （P 〈 0.05）. Conclusions The expression of Cathepsin-D is correlated positively with histological type and promotes the infiltration and development of mucoepidermoid carcinoma in salivary gland. Cathepsin-D acts as a predictor of the clinical treatment.