慢性阻塞性肺疾病急性加重期患者血浆炎症因子与生长激素释放肽水平的变化

Changes of plasma inflammatory factors and ghrelin in patients with acute exacerbation of chronic obstructive pulmonary disease

目的探讨C-反应蛋白(CRP)、白细胞介素8(IL-8)和生长激素释放肽(ghrelin)在慢性阻塞性肺疾病急性加重期(AECOPD)中的变化。方法测定20例男性AECOPD患者(A组)治疗前、后和20例男性健康人(C组)血浆CRP、IL-8和ghrelin水平。结果 A组治疗前、后血浆CRP、IL-8和ghrelin水平均高于C组(P<0.05或P<0.01),A组治疗后血浆CRP、IL-8和ghrelin水平较治疗前均有明显降低(P<0.01)。A组血浆CRP、IL-8与ghrelin水平呈正相关。结论 AECOPD患者血浆CRP、IL-8及ghrelin水平均显著增高,ghrelin可能通过影响炎症因子的水平参与了AECOPD的发病与发展。

Objective To investigate the changes of plasma inflammatory factors and ghrelin in patients with acute exacerbation of chronic obstructive pulmonary disease（AECOPD）.MethodsThe plasma C-reactive protein（CRP）,interleukin-8（IL-8） and growth hormone-releasing peptide（ghrelin） were detected in 20 male patients with AECOPD（group A） and 20 healthy men as the controls（group C）.Results The plasma levels of CRP,IL-8 and ghrelin were higher in group A before and after treatment than those in group C（P0.05 or P0.01）,which in group A were lower after treatment than those before（P0.01）.The plasma level of CRP and IL-8 in group A was positively correlated with that of ghrelin.Conclusion The plasma levels of CRP,IL-8 and ghrelin in the patients with AECOPD are significantly higher.Ghrelin may take a role in the pathogenesis and development of AECOPD by affecting the level of inflammation factors.