摘要
目的探讨C-反应蛋白(CRP)、白细胞介素8(IL-8)和生长激素释放肽(ghrelin)在慢性阻塞性肺疾病急性加重期(AECOPD)中的变化。方法测定20例男性AECOPD患者(A组)治疗前、后和20例男性健康人(C组)血浆CRP、IL-8和ghrelin水平。结果 A组治疗前、后血浆CRP、IL-8和ghrelin水平均高于C组(P<0.05或P<0.01),A组治疗后血浆CRP、IL-8和ghrelin水平较治疗前均有明显降低(P<0.01)。A组血浆CRP、IL-8与ghrelin水平呈正相关。结论 AECOPD患者血浆CRP、IL-8及ghrelin水平均显著增高,ghrelin可能通过影响炎症因子的水平参与了AECOPD的发病与发展。
Objective To investigate the changes of plasma inflammatory factors and ghrelin in patients with acute exacerbation of chronic obstructive pulmonary disease(AECOPD).MethodsThe plasma C-reactive protein(CRP),interleukin-8(IL-8) and growth hormone-releasing peptide(ghrelin) were detected in 20 male patients with AECOPD(group A) and 20 healthy men as the controls(group C).Results The plasma levels of CRP,IL-8 and ghrelin were higher in group A before and after treatment than those in group C(P0.05 or P0.01),which in group A were lower after treatment than those before(P0.01).The plasma level of CRP and IL-8 in group A was positively correlated with that of ghrelin.Conclusion The plasma levels of CRP,IL-8 and ghrelin in the patients with AECOPD are significantly higher.Ghrelin may take a role in the pathogenesis and development of AECOPD by affecting the level of inflammation factors.
出处
《江苏医药》
CAS
CSCD
北大核心
2011年第24期2941-2942,共2页
Jiangsu Medical Journal