新型抗精神病药:阿塞那平

A new type of antipsychotic drug:asenapine

阿塞那平(asenapine)是一种新型非典型抗精神病药物,为5-HT受体、α-肾上腺素受体、多巴胺D受体及组胺H受体的拮抗药,对M胆碱受体没有亲和力。阿塞那平主要用于治疗成人的急性精神分裂症,以及双相情感障碍Ⅰ型的急性躁狂发作或混合性发作(伴/不伴精神病性症状)。现有资料提示该药具有良好的有效性和安全性,但仍需要长期使用的资料积累。

Asenapine as a new atypical antipsychotic agent is an antagonist of serotonin 5-HT,α-adrenergic, dopamine D and histamine H receptors,and displays very low affinities for muscarinic M receptor. Asenapine has been approved for the acute treatment of schizophrenia in adults and the acute treatment of manic or mixed episodes associated with bipolar I disorder,with or without psychotic features,in adults.Although the present clinical data show that it is effective and safe,further studies for long term observation are necessary.