胰岛素样生长因子2的表达对N2期肺腺癌预后的影响

Impact of Insulin-like Growth Factor 2 Expression on Prognosis of Lung Adenocarcinoma with Mediastnal Lymphnode Metastasis

目的:本研究探讨了IGF2在N_2期肺腺癌组织中的表达及其对预后的影响。方法:回顾性分析90例未行新辅助化疗的N_2期肺腺癌患者情况,利用石蜡标本组织制成组织芯片,行免疫组化检测,研究影响N_2期肺腺癌的预后因素,以及IGF2的表达对预后的影响。结果:N_2期肺腺癌手术后的5年生存率与隆突下淋巴结是否转移、T分期及纵隔淋巴结转移站数有关。IGF2在N_2期肺腺癌中表达的阳性率是68.9%。IGF2阳性表达的N_2期肺腺癌的5年生存率为8.0%,IGF2阴性表达的N_2期肺腺癌的5年生存率为18.0%,两者有显著性差异(P=0.034)。结论:N_2期肺腺癌的预后差,影响其预后的临床因素包括T分期、纵隔淋巴结转移站数和隆突下淋巴结转移。IGF2表达有预测N_2期肺腺癌预后的作用。

Objective： Insulin-like growth factor 2 had a high expression in many cancers. In the current paper, the expression ot Insulin-like growth factor 2 was investigated and its prognostic significance in lung adenocarcinoma with mediastinal lymph node metastasis was studied. Methods： A retrospective immunohistological analysis of specimens of lung adenocarcinoma with mediastinal lymphnode metastasis was conducted. All patients did not have neoadjuvant chemotherapy and/or radiotherapy. The prognostic factors of stage N2 lung adenocarcinoma and the impact of insulin-like growth factor 2 on the prognosis of patients with stage N2 lung adenocarcinoma were also studied. Results： Factors including T stage, station 7 metastasis, and the number of metastatic stations had an impact on the prognosis of stage N2 lung adenocarcinoma. The 5-year overall survival of patients with negative and positive expression of insulin-like growth factor 2 were 18% and 8%, respectively （ P = 0.034 ）. Conclusion： The prognosis of stage N2 lung adenocarcinoma is poor. The prognostic factors of stage N2 lung adenocarcinoma include the T stage, station 7 metastasis, the number of metastatic stations, and the expression of insulin-like growth factor 2.