摘要
目的探讨分泌型蛋白Dickkopf-1(Dkk-1)在溃疡性结肠炎及大肠癌患者血清中的表达情况及其临床意义。方法采用ELISA法检测56份溃疡性结肠炎患者、50份大肠癌患者及60份健康人血清中Dkk-1水平,并以统计学分析其差异性。结果56例溃疡性结肠炎患者血清中Dkk-1水平均有不同程度降低,40例溃疡性结肠炎中重度患者及50例大肠癌患者较正常对照组明显降低,其差别具有显著性意义(P<0.05)。结论中重度溃疡性结肠炎及大肠癌患者血清Dkk-1水平明显低于健康人,提示Dkk-1与大肠癌疾病进展相关,其可能作为疾病监测的指标,但有待大样本进一步验证。
Objective To evaluate serum Dickkopf-l（Dkk-1） concentrations in patients with ulcerative colitis or colorectal cancer. Methods By use of ELISA, we investigated the serum concentrations of Dkk-1 in 56 patients with ulcerative colitis, 60 patients with colorectal cancer and 60 healthy controls. One-way ANOVA was used for statistics. Results Serum Dkk-1 concentration decreased in patients with ulcerative colitis, but there was only a significant difference between medium- and severe- ulcerative colitis and control group （P 〈 0.05）. The serum Dkk-1 concentration also decreased in patients with colorectal cancer, the difference was significant （P 〈 0.05）. Conclusion Dkk-1 has close relationship with ulcerative colitis and colorectal cancer progression, and could be used as a potential biomarker.
出处
《现代消化及介入诊疗》
2011年第6期359-361,共3页
Modern Interventional Diagnosis and Treatment in Gastroenterology
基金
广东省医学科研基金(A2009404)
