微波辅助合成查尔酮衍生物的工艺

Synthetic Process Optimization of Chalcone Derivative under Microwave Irradiation

本文应用微波辐射技术,以苯甲醛衍生物(1a～1d)和苯乙酮衍生物(2e,2f)为原料,合成了8种查尔酮衍生物(3a～3d,4a～4d),它们是重要的有机中间体,其结构经1H NMR,IR,MS和元素分析表征;研究了查尔酮3a的合成工艺,考察了物料比微波辐射时间辐射功率对产率的影响,通过正交实验确定查尔酮的最佳合成条件为:苯甲醛与苯乙酮的物质的量之比1∶1,微波功率140W,微波反应时间为25min,产率85%～92%。

Eight chalcone derivatives（3a^3d,4a^4d）were synthesized by benzaldehyde（2e,2f） and substituted acetonphenone（1a^1d）under microwave irradiation conditions,which is to further study the preparation of new pyrazoline.The structures were confirmed by 1H-NMR,IR,MS and elementary analysis.The synthesis technology chalcone（3a） was studied.Effects of raw materials mole ratio,reaction time and microwave radiation power on the reaction yield were investigated.The optimal synthesis conditions are benzaldehyde to acetophenone mole ratio,microwave power reaction,microwave irradiation time.The synthesis reaction were easily worked up with short time,high yields and green initiative.