集体心理治疗合并喹硫平对精神分裂症患者主观舒适度影响的随机对照研究

A comparative study of effect on subjective well-being of patients with schizophrenia by group psychotherapy combined with Quetiapine

目的:探讨集体心理治疗对住院精神分裂症患者主观舒适度的影响。方法:将符合入组标准的80位患者随机分为集体心理治疗合并喹硫平治疗组(研究组)和仅采用喹硫平治疗组(对照组)各40例,观察时间为6周。采用阳性和阴性症状量表(PANSS),"抗精神病药物治疗中主观舒适度(SWN)简表"评价疗效。结果:治疗后研究组的PANSS的阴性因子分显著低于对照组,SWN各因子分均有提高,其中研究组总分及精神功能情感调节、社会适应分量表得分与治疗前差异显著;治疗后两组比较,研究组情感调节、社会适应分量表得分显著高于对照组。结论:集体心理治疗不仅可以改善精神分裂症患者阴性症状,还能明显改善患者在治疗中的主观舒适度,有利于提高患者生活质量和健康水平。

Objective：To explore the effect on subjective well-bing in the treatment of schizophrenia by group psychotherapy combined with Quetiapine.Methods：80 patients with schizophrenia were randomly divided into two groups：Study group（40 cases）was treated by group psychotherapy and Quetiapine and Control group（40 cases）was only treated by Quetiapine for 6 weeks.The therapeutic effects were assessed with positive and negative syndrome scale（PANSS） and subjective well-bing under weuroleptics（SWN） short form.Results： The scores of negative factors of PANSS in study group was significantly lower than that in Control group after 6 weeks.All subscale scores of SWN in two groups were improved.In study group the total scores and subscale scores of mental functioning emotional regulation,and social integration after treatment were significantly higher than that before treatment,and in control group only subscale score of mental functioning was significantly higher.Conclusions： It＇s beneficial to improve negative symptoms and subjective well-bing of schizophrenia with group psychotherapy and the quality of life and level of rehabilitation will bi increased.