肿瘤辐射增敏剂尼可胺的一般药理学研究

Study on General Pharmacology of Tumor Radio-sensitization Agent Nikean

目的:研究新型肿瘤辐射增敏剂尼可胺的一般药理学。方法:取小鼠随机分为溶媒对照组和尼可胺低、中、高剂量(375、750、1500mg.kg-1)组,每组10只,尾静脉注射相应药物,考察给药后各组小鼠的主动活动次数和平衡能力。取犬随机分为溶媒对照组和尼可胺低、中、高剂量(180、360、540mg.kg-1)组,每组6只,股静脉注射相应药物,考察各组犬给药前后不同时间的血压、心电图、心率、心律以及呼吸频率和幅度的变化情况。结果:与溶媒对照组比较,尼可胺各剂量组小鼠的自主活动次数和平衡能力无明显变化,但高剂量组上述2项指标有下降趋势;尼可胺各剂量组犬给药前后不同时间的血压、心电图、心率、心律以及呼吸频率和幅度均无明显变化。结论:尼可胺1500mg.kg-1对小鼠的中枢神经系统有一定影响,但不显著;尼可胺在本实验用药剂量下对犬心血管系统、呼吸系统的生理功能均无明显影响。

OBJECTIVE： To study general pharmacology of tumor radio-sensitization agent nikean. METHODS： Mice were ran- domized into solvent control group, nikean high-dose, medium-dose and low-dose groups （375 mg-kg-1, 750 mg.kg-1, 1 500 mg. kg-1）, respectively with 10 mice in each group. Those groups were administered with relevant medicine via tail intravenous vein. The free action and balance capacity of mice were investigated. Experimented dogs were also divided into solvent control group, nikean high-dose, medium-dose and low-dose groups （ 180 mg. kg- 1, 360 mg. kg- 1, 540nag. kg- ~） groups, respectively with 6 dogs in each group. Those dogs were administered with relevant medicine via buttock intravenous vein. The blood pressures, electro- cardiogram, heart rate, heart rhythm, and breathing rate and depth in anaesthesized dogs were also investigated. RESULTS：Compared with solvent control group, nikean groups had no obvious change in free action and balance capacity of mice. Nikean high-dose group had some decline in above two indexes. Nikean groups had no obvious change in blood pressure, electrocardiogram, heart rate, heart rhythm, respiratory frequency and depth Of anaesthesized dogs. CONCLUSION：Nikean 1 500 mg-kg-1 has some impact on central nervous system in mice, but unobviously. Under this experimental condition, nikean has no impact on physiological functions of cardiovascular and respiratory system in dogs.