牛膝中一个新的阿魏酰胺苷(英文)

A new feruloyl tyramine glycoside from the roots of Achyranthes bidentata

目的:研究牛膝的化学成分。方法:采用D101型大孔吸附树脂、硅胶、ODS和制备型高效液相色谱等分离手段,运用NMR等波谱技术鉴定化合物的结构。结果:从牛膝中分离并鉴定了2个阿魏酰胺苷和7个皂苷类化合物:N-trans-feruloyl-3-methoxytyramine-4′-O-β-D-glucopyranoside(1),N-trans-feruloyl-3-methoxytyramine-4-O-β-D-glucopyranoside(2),PJS-1(3),chikusetsusaponinIVa(4),oleanolicacid3-O-[β-D-glucuronopyranoside-6-O-methylester]-28-O-β-D-glucopyranoside(5),oleanolicacid3-O-[β-D-glucuronopyranoside-6-O-ethylester]-28-O-β-D-glucopyranoside(6),oleanolicacid3-O-[β-D-glucurono-pyranoside-6-O-butylester]-28-O-β-D-glucopyranoside(7),ginsenosideR0(8)和hederagenin-28-O-β-D-glucopyranosylester(9)。结论:化合物1为新化合物,化合物2和9为首次从该植物中分离得到。

AIM： To study the chemical constituents of the roots of Achyranthes bidentata B1.. METHODS： The chemical constituents were isolated and purified by macroporous adsorptive resin D101, silica gel, and ODS column chromatographies and preparetive HPLC. Their structures were elucidated on the basis of 1D and 2D NMR analyses. RESULTS： Two feruloyl tyramine glycosides and seven triterpenoid saponins were obtained and identified as N-trans-feruloyl-3-methoxytyramine-4＇-O-β-D-glucopyranoside （1）, N-trans-feruloyl-3-methoxytyra mine-4-O-β-D-glucopyranoside （2）, PJS-1 （3）, chikusetsusaponin IVa （4）, oleanolic acid 3-0- [β-D-glucuronopy ranoside-6-O-methyl ester]-28-O-β-D-glucopyranoside （5）, oleanolic acid 3-O-[β-D-glucuronopyran-oside-6-O- ethyl ester]-28-O-β-D-glucopyranoside （6）, oleanolic acid 3-O-[β-D-glucuronopyranoside-6-O-butyl ester]-28-O-β-D-glucopyranoside （7）, ginsenoside R0 （8） and hederagenin-28-O-β-D-glucopyranosyl ester （9）. CONCLUSION： Compound 1 is a new feruloyl tyramine glycoside, while compounds 2 and 9 are reported from A. bidentata for the first time.