摘要
IL-35是一种由调节性T细胞（Tr）分泌具有免疫负调作用的新型细胞因子。IL-35通过抑制IL-17等效应分子发挥免疫调节作用，研究表明，Tr、IL-35和Th17参与了自身免疫性疾病，炎症与肿瘤的免疫调节，因此IL-35的上游激活以及下游效应反应机制值得进一步研究探讨。
IL-35, a novel inhibitory cytokine, is specifically produced by regulatory T cell （Tr）. It has been proven that IL-35 can negatively regulate the expression of IL-17 and other molecules and plays a role in immune regulation. Studies have shown that Tr, IL-35 and Thl7 are involved in autoimmune diseases, inflammation and tumor immune. Therefore, the mechanism about the activation of IL-35 and its downstream effects should be further studied.
出处
《国际免疫学杂志》
CAS
2012年第1期18-21,共4页
International Journal of Immunology
基金
上海市自然科学基金资助项目（10ZR1420000）
