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C-型凝集素家族在Th17细胞免疫反应中的作用

The roles of C-type lectins in Th17 responses
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摘要 Th17细胞是近年来发现的一群新的细胞亚群,在感染、自身免疫性及肿瘤等疾病中发挥重要作用,是目前研究的热点之一。而C-型凝集素是一类重要的模式识别受体,能调节Th1细胞和Th17细胞间的免疫平衡,识别真菌等多种病原体,在抗感染免疫中具有重要作用。近年来有大量的研究发现,多种C-型凝集素受体参与Th17细胞的分化。因而对其深入研究可明确疾病的发病机制,为疾病的治疗提供了新的思路和靶点。 Thl7 cells, a subtype of CD4^+ T helper cells, mainly produce IL-17 and IL-22, and are linked to host defense against infections, autoimmunity and tumors. The C-type lectin receptors are a type of important pattern recongnition receptors,which are capable of regulating the balance between Thl and Thl7 responses . Many of these receptors recognise fungi, and other pathogens. Thus, they play key roles in the development of protective anti-microbial immunity. The roles of C-type lectins in the differentionation of Thl7 has beenindicated recently. Understanding the ligands and signaling might reveal new therapeutic targets for diseases.
出处 《国际免疫学杂志》 CAS 2012年第1期50-53,共4页 International Journal of Immunology
关键词 TH17细胞 C-型凝集素 IL-17 Thl7 C-type leetin Interleukin-17
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参考文献33

  • 1Batteli E, Korn T,Kuchroo VK. Thl7:the tbird member of the effector 3' cell trilogy. Curt Opin Immuno1,2007 : 19 (6) :652-657.
  • 2Sa S M, Valdez P A, Wu J et al. The effect of IL-20 subfamily cytokines on reconstituted human epidermis suggest potential roles in cutaneous innate defense and pathogenic adaptive immunity in psoriasis. J Immunol,2007 : 178 (4) :2229-2240.
  • 3Matt L, Liang S, Li I et al. IL-22 is required for Thl7 cell-mediated pathology is a mouse model of psoriasis-like skin inflammation. J Clin Invest ,2008 : 118 (2) :597-607.
  • 4Zenewicz L A, Yancopoulos G D, Valenzuela D M et al. Interleu-kin-22 but not Interleukin-17 provides protection to hepatocytes during acute liver inflammation. Immunity, 2007 : 27 (4) : 647- 659.
  • 5Chang H, Hanawa H, lin H et al. Hydrogynamic-based delivery of an IL-22-Ig fusion gene ameliorates experimental autoimmune myocarditis in rats. J Immunol, 2006 : 177 (6) :3635-3643.
  • 6Levillaycr F, Mas M, Levi-Acobas F et al. IL-22 is a candidate gene for Timevp3, a locu controlling Theiler~ virus-induced neurological diseased. Genetics, 2007 : 176 (3) : 1835-1844.
  • 7Misse D,Yssel H,Trabattoni D et al. IL-22 Participates in an in- hates anti-HIV-I host-resistance network through acute-phase protein induction. J Immunol, 2007 : 178( 1 ) :407415.
  • 8Aujla S T,Chan Y R,Zheng M et al. IL-22 mediates mucosal host defense against Gram-negative bacterial pneumonia. Nat Med, 2008 : 14 ( 3 ) : 275-281.
  • 9Zheng Y, Valdez P A, Danilenko D M et al. IL-22 mediates early host defense against attaching and effacing bacterial pathogens. Nat Med,2008 : 14 (3) :282-289.
  • 10Weber G F, Schlaulkotter S, Kaiser-Moore S et al. Inhibition of IL-22 attenuates bacterial load and organ failure during acute polymicrobial sepsis. Infect Immun, 2007:75 (4) : 1690-1697.

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