C-型凝集素家族在Th17细胞免疫反应中的作用

The roles of C-type lectins in Th17 responses

Th17细胞是近年来发现的一群新的细胞亚群，在感染、自身免疫性及肿瘤等疾病中发挥重要作用，是目前研究的热点之一。而C-型凝集素是一类重要的模式识别受体，能调节Th1细胞和Th17细胞间的免疫平衡，识别真菌等多种病原体，在抗感染免疫中具有重要作用。近年来有大量的研究发现，多种C-型凝集素受体参与Th17细胞的分化。因而对其深入研究可明确疾病的发病机制，为疾病的治疗提供了新的思路和靶点。

Thl7 cells, a subtype of CD4^＋ T helper cells, mainly produce IL-17 and IL-22, and are linked to host defense against infections, autoimmunity and tumors. The C-type lectin receptors are a type of important pattern recongnition receptors,which are capable of regulating the balance between Thl and Thl7 responses . Many of these receptors recognise fungi, and other pathogens. Thus, they play key roles in the development of protective anti-microbial immunity. The roles of C-type lectins in the differentionation of Thl7 has beenindicated recently. Understanding the ligands and signaling might reveal new therapeutic targets for diseases.