慢性原发性失眠患者的前瞻性记忆研究

A study on prospective memory in chronic primary insomnia

目的探讨慢性失眠对患者前瞻性记忆的损害情况。初步探讨慢性失眠引起前瞻性记忆损害的可能神经机制。方法采用前瞻性记忆的神经心理学测试方法，对42例慢性原发性失眠患者及40名正常睡眠者进行基于事件和基于时间的前瞻性记忆测试。结果与正常睡眠组[（5．58±0．35）分]比较，慢性原发性失眠组[（3．44±0．40）分]患者基于事件的前瞻性记忆差异有统计学意义（t=3．933，P=0．000）；基于事件的前瞻性记忆的回溯成分差异无统计学意义（t=1．308，P=0．195）；基于时间的前瞻性记忆差异无统计学意义（t=0．787，P=0．433）；基于时间的前瞻性记忆的回溯成分差异无统计学意义（Z=-0．776，P=0．437）。结论慢性失眠影响患者基于事件的前瞻性记忆，而基于时间的前瞻性记忆及回溯成分相对正常。

Objective To explore the characteristics and the pathogenetic mechanism of prospective memory in patients with chronic primary insomnia. Methods Forty-two patients with chronic primary insomnia and forty age, gender, education, and cultural level matched healthy adults were assessed with a battery of neuropsychological tests including event-based prospective memory （ EBPM ） and time-based prospective memory （TBPM） tasks. Results Compared with the healthy controls （EBPM ：5.58±0. 35; TBPM： 4. 10 ± 0. 32） , the patients with chronic primary insomnia had a significant loss in EBPM （3.44±0.40, t = 3. 933, P = 0. 000） , but a insignificant impairment in TBPM （3.76±0. 29, t = 0. 787, P = 0. 433 ）. The retrospective component of event-based prospective memory between the two groups had no significant difference （ t = 1. 308, P = 0. 195 ） , neither did the retrospective component of time-based prospective memory （ Z = - 0. 776, P = 0. 437 ）. Conclusion These results suggest that the patients with chronic primary insomnia have impairment in EBPM, but not in TBPM and the retrospective component of prospective memory.