摘要
目的探讨慢性失眠对患者前瞻性记忆的损害情况。初步探讨慢性失眠引起前瞻性记忆损害的可能神经机制。方法采用前瞻性记忆的神经心理学测试方法,对42例慢性原发性失眠患者及40名正常睡眠者进行基于事件和基于时间的前瞻性记忆测试。结果与正常睡眠组[(5.58±0.35)分]比较,慢性原发性失眠组[(3.44±0.40)分]患者基于事件的前瞻性记忆差异有统计学意义(t=3.933,P=0.000);基于事件的前瞻性记忆的回溯成分差异无统计学意义(t=1.308,P=0.195);基于时间的前瞻性记忆差异无统计学意义(t=0.787,P=0.433);基于时间的前瞻性记忆的回溯成分差异无统计学意义(Z=-0.776,P=0.437)。结论慢性失眠影响患者基于事件的前瞻性记忆,而基于时间的前瞻性记忆及回溯成分相对正常。
Objective To explore the characteristics and the pathogenetic mechanism of prospective memory in patients with chronic primary insomnia. Methods Forty-two patients with chronic primary insomnia and forty age, gender, education, and cultural level matched healthy adults were assessed with a battery of neuropsychological tests including event-based prospective memory ( EBPM ) and time-based prospective memory (TBPM) tasks. Results Compared with the healthy controls (EBPM :5.58±0. 35; TBPM: 4. 10 ± 0. 32) , the patients with chronic primary insomnia had a significant loss in EBPM (3.44±0.40, t = 3. 933, P = 0. 000) , but a insignificant impairment in TBPM (3.76±0. 29, t = 0. 787, P = 0. 433 ). The retrospective component of event-based prospective memory between the two groups had no significant difference ( t = 1. 308, P = 0. 195 ) , neither did the retrospective component of time-based prospective memory ( Z = - 0. 776, P = 0. 437 ). Conclusion These results suggest that the patients with chronic primary insomnia have impairment in EBPM, but not in TBPM and the retrospective component of prospective memory.
出处
《中华神经科杂志》
CAS
CSCD
北大核心
2012年第1期36-39,共4页
Chinese Journal of Neurology
基金
国家科技支撑计划资助项目(2009BA177B06)
关键词
入睡和睡眠障碍
神经心理学测验
记忆
前瞻性研究
Sleep initiation and maintenance disorde
Neuropsychological tests
Memory
Prospective studie