克拉霉素分散片治疗轻症小儿支原体肺炎80例报告

Application of Clarithromycin Dispersible Tablet in the Treatment of Children with Mild Mycoplasmal Pneumonia

目的:观察克拉霉素分散片治疗轻症小儿支原体肺炎的疗效与安全性。方法:将80例轻症支原体肺炎患儿随机分为研究组和对照组,每组40例,分别用克拉霉素分散片与阿奇霉素分散片治疗7-14d,对2组临床疗效、症状消退时间、疗程和不良反应进行观察比较。结果:第1个疗程结束,研究组痊愈率62.5%、显效率82.5%、有效率92.5%,第2个疗程结束分别为82.5%、90%和92.5%,症状体征评分和症状体征消退时间及疗程,两组间差异无统计学意义(均P>0.05)。不良反应两组间差异无统计学意义(P>0.05)。结论:克拉霉素分散片治疗轻症小儿支原体肺炎疗效确切,与阿奇霉素分散片相当,且安全性好、使用方便。

Objective： To observe the clinical efficacy and safety of clarithromycin dispersible tablet in the treatment of children with mild mycoplasmal pneumonia.Methods： All 80 children with mild mycoplasmal pneumonia were randomly and equally assigned into clarithromycin group and azithromycin group,and all cases were treated respectively for 7-14 days.The clinical efficacy,adverse effect,symptoms remission,and treatment times in two groups were observed and compared.Results： The cure rate,effective rate,and the total improved rate in clarithromycin group was 62.5%,82.5%,and 92.5% respectively after the first treatment course,and 82.5%,90%,and 92.5% respectively after the second treatment course.But the clinical efficacy had no significant difference between the two groups（all P0.05）,as well as the scores of symptoms,the incidence of adverse effects,the time to remission and time of treatment.Conclusion： Clarithromycin dispersible tablet has a good efficacy in the treatment of children with mild mycoplasmal pneumonia.Its efficacy is as good,safe and convenient as that of azithromycin dispersible tablet.