疏肝肺积方结合心理干预对原发性肺癌患者生存质量的影响

Effects of Feiji Decoction for Soothing the Liver Combined with Psychotherapy on Quality of Life in Primary Lung Cancer Patients

背景与目的原发性支气管肺癌是最常见的恶性肿瘤,带给患者巨大的躯体病痛和情绪障碍,而且明显降低患者的生存质量,本实验旨在研究疏肝肺积方结合心理干预对原发性肺癌患者生存质量、体能状态的影响。方法将118例原发性非小细胞肺癌患者随机分为两组:疏肝肺积方结合心理干预加化疗组(联合治疗组57例)和单纯化疗组(61例)。联合治疗组采用疏肝肺积方和心理干预与化疗的联合应用;单纯化疗组仅接受化疗,共完成2次化疗,为1个总疗程。采用欧洲癌症研究与治疗组织生命质量核心量表(European Organization for Research and Treatment of Cancer QoL Questionnaire,EORTC QLQ-C30)和肺癌患者生命质量测定特异性模块(EORTC QLQ-LC13)测定生存质量,卡氏评分(Karnofsky performance status,KPS)和ECOG评分(East Cooperative Oncology Group performance status)测定体能状态。结果联合治疗组生理、角色、情感、认知、社会功能以及总健康状况领域的评分比单纯化疗组的评分高,生存质量更好,且具有统计学意义(P<0.01);联合治疗组疲倦、恶心呕吐、疼痛、气促、失眠、食欲丧失、便秘症状以及肺癌特异症状评分比单纯化疗组的评分低,缓解更明显,且具有统计学意义(P<0.01);联合治疗组卡氏评分和ECOG评分提高和稳定的患者多于单纯化疗组,且具有统计学意义(P<0.01)。结论疏肝肺积方结合心理干预能缓解肺癌患者的临床症状、改善体能状态、提高生存质量,具有较好的临床疗效。

Background and objective Primary lung cancer is one of the most common malignant tumors. It causes great pain and mood disorders to patients, and signi cantly reduces their quality of life.The aim of the current study is to evaluate the effect of Feiji Decoction for soothing the liver combined with psychotherapy on quality of life （QoL） and physical status of patients with primary lung cancer. Methods A total of 118 patients with primary non-small cell lung cancer were randomly divided into two groups. e 57 patients in the combined therapy group were treated with Feiji Decoction for soothing the liver and psychotherapy combined with chemotherapy, whereas the 61 patients in the control group were treated with chemotherapy only. Both groups were observed for the two treatment courses. e European Organization for Research and Treatment of Cancer QoL Questionnaire LC-43 （EORTC QLQ-LC43） was used to assess the QoL of every patient in both groups before and a er treatment scales. At the same time, physical status was assessed using the Karnofsky performance status （KPS） and East Cooperative Oncology Group performance status （ECOG）. Results e scores of physiology function, role function, emotion function, cognize function, society function, and general health in the therapy group were higher than that of the control group. e therapy group also showed be er QoL results than the contol group. Signi cant di erences were observed between the two groups （P0.01）. Meanwhile, the scores of fatigue, vomit, pain, polypnea, insomnia, anorexia, constipation, and speci c manifestation of lung cancer in the therapy group were obviously lower than that of the control group; more patients were observed to be relieved. Signi cant di erences between the two groups were observed （P0.01）. e KPS and ECOG scores of the patients were observed to have improved and stabilized in the therapy group than that of the controlgroup; the di erences were statistically signi cant （P0.01）. Conclusion Feiji Decoction for soothing the liver combined with psychotherapy can alleviate the clinical symptoms, elevate the physical status, and improve the QOL of patients with primary lung cancer. us, this therapy has a good clinical therapeutic effect.