多沙唑嗪对于改善输尿管支架管引起的下尿路症状的作用

The effect of doxazosin in improving symptoms and quality of life for patients with indwelt double-J ureteral stents

目的评价多沙唑嗪对置入输尿管支架管(D-J)患者下尿路症状以及生活质量的改善作用。方法从2010年3月至2010年12月,共收集了28例输尿管镜碎石后留置D-J管的患者入组本研究。患者被随机分为2组(治疗组、对照组),对照组14例患者未接受多沙唑嗪治疗,治疗组14例患者接受了2～4周的多沙唑嗪(4mg/d)治疗。所有患者均在2～4周后D-J管去除之前接受国际前列腺症状评分和世界卫生组织生存质量测定量表简表对患者下尿路症状及生存质量进行评估。结果对照组IPSS平均分为9.79,治疗组中IPSS平均分为5.07,P<0.05;对照组中生理领域平均分为13.80,治疗组中为15.43,P<0.05。结论多沙唑嗪可改善一系列D-J管相关下尿路症状以及患者的生活质量。

Objective To evaluate the effect of doxazosin in improving symptoms and quality of life for patients with indwelt double-J ureteral stents.Methods Between March 2010 to Sept.2010,a total of 28 patients with indwelt double-J ureteral stents after ureteroscopic stone removal were enrolled in this study.Patients were prospectively randomized into two groups.14 patients in Group 1 didn＇t receive doxazosin therapy.Another 14 patients in Group 2 received doxazosin（4 mg/day） for 2 to 4 weeks.All patients completed the International Prostate Symptom Scale（IPSS） and the brief version of the World Health Organization Quality of Life Instrument for evaluating lower urinary tract symptoms and quality of life before double-J stent removal 2 to 4 weeks later.Results The mean score of IPSS was 9.79 in Group 1 and 5.07 in Group 2,P0.05;the mean score of physical domain was 13.80 in Group 1 and 15.43 in Group 2,P0.05.Conclusions Doxazosin improved a subset of stent-related lower urinary tract symptoms and quality of life.