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二氯乙酸盐治疗肿瘤的机制研究进展 被引量：1

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摘要 二氯乙酸盐可以通过抑制丙酮酸脱氢酶激酶、增加进入线粒体的丙酮酸流量、促进糖氧化,抑制肿瘤中的糖酵解。这种作用可以逆转功能紊乱的线粒体,使其恢复功能并促进肿瘤细胞凋亡,从而抑制肿瘤细胞的生长。本文将对近年来二氯乙酸盐治疗肿瘤的机制研究进展做一综述。
作者 陈彦博 王忠 周娟
机构地区 上海交通大学医学院附属第九人民医院泌尿外科
出处 《现代泌尿外科杂志》 CAS 2012年第1期106-108,共3页 Journal of Modern Urology
基金 国家自然科学基金(No.81070544) 上海市科委项目(No.08140901700)
关键词 二氯乙酸盐 糖酵解 Warburg效应
分类号 R730.53 [医药卫生—肿瘤]
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同被引文献11

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