喹诺酮类药物临床应用及不良反应

Clinical application of quinolone antibiotics and analysis of adverse reactions

目的对喹诺酮类抗菌药物的结构特点、抗菌谱及临床应用范围、不良反应进行分析。方法对医院2010年喹诺酮类抗菌药物临床处方进行统计,分析其药品临床使用处方数、频率和排序及喹诺酮类药物的用途及作用。结果喹诺酮类药物使用频率=药品处方数/药品总处方数,其中使用频率最高的前3位为诺氟沙星、依诺沙星和氧氟沙星,占喹诺酮类抗菌药物处方总量的85.3%,在抗菌药物中运用广泛。结论喹诺酮类在抗菌药物中占有重要地位,应规范、合理应用,防止造成药物不良反应。

OBJECTIVE To analyze the structure feature of quinolone antibacterials, antibacterial spectrum and clinical application and adverse reactions. METHODS The clinical prescriptions on quinolone antibacterial statistics in 2010 were analyzed, including the drug using times, frequency and sorting, as well as the using purpose of quinolone drugs and the effects. RESULTS The quinolone drug using frequency= appearing times of a drug on prescriptions/total number of prescriptions. The top three antibiotics most frequently used were nofloxacin, ciprofloxacin and ofloxacin, which were widely used and accounted for 85.3% of quinolone prescription drugs on prescriptions. CONCLUSION Quinolone drugs are important antibiotics which should be used reasonably and standardly to avoid adverse drug reactions.