306例非肿瘤患者侵袭性肺部真菌感染的调查分析

Clinical research of invasive pulmonary fungal infection in 306 patients without tumor

目的探讨非肿瘤患者侵袭性肺部真菌感染(IPFI)的临床特点。方法选取2008年1月-2010年5月河北省13所医院呼吸科,IPFI患者306例,收集患者的微生物学、影像学与临床诊治资料等,分析临床特点。结果306例患者共分离出真菌336株,其中白色假丝酵母菌145株,抗真菌药物有效率以伏立康唑最高达71.4%。结论宿主因素对于IPFI的早期诊断与预防至关重要;IPFI的致病真菌仍以假丝酵母菌属最多。

OBJECTIVE To find out and master clinical characteristics of invasive pulmonary fungal infection （IPFI） in the patients without tumor. METHODS A retrospective study was conducted on 306 IPFI patients from department of respiratory diseases in thirteen hospitals of Hebei province from Jan 2008 to May 2010. The clinical data were collected, which included diagnosis and treatment, microbiology, imaging presentation, etc. Based on the above information, the clinical characteristics of IPFI were analyzed. RESULTS A total of 306 cases were investigated. Totally 336 strains of fungi were isolated from those cases. 145 strains of them were Candida albicans. The most effective antimicrobial was voriconazole （71.4%）. CONCLUSION Host factors are very important to the early diagnosis and prevention for IPFI. The most common pathogenic fungus in the group is Candida.