南阳市反流性食管炎的临床流行病学研究

Study on Clinical Epidemiology of Reflux Esophagieis in Nanyang City

目的分析南阳地区反流性食管炎的临床流行病学特点。方法南阳医学高等专科学校第一附属医院2007年7月-2009年12月经胃镜检查诊断为反流性食管炎488例,分析其发病率及年龄分布、伴发疾病主要症状发生的危险因素、幽门螺杆菌感染率,并与同期其他胃肠疾病的幽门螺杆菌感染率相对照。结果反流性食管炎的发病率为4%,男女比例为5.1∶1,发病年龄以中年为主,平均年龄45岁。反流性食管炎的幽门螺杆菌感染率为21.1%,明显低于同期其他胃肠病幽门螺杆菌感染率45.2%(P<0.01);主要伴发疾病为十二指肠球部溃病、食管裂孔疝。本地区常见的高危因素为大量饮酒、大量吸烟及长期服用非甾体类药物。根据洛杉矶标准,内镜下反流性食管炎分级以A、B级为主(发病率90.9%)。结论本地区反流性食管炎的发病以轻中度为主,中、老年男性为高发人群;幽门螺杆菌在反流性食管炎有较低的感染率;反流性食管炎主要伴发疾病为十二指肠球部溃疡、食管裂孔疝。其主要症状发生的高危因素为大量饮酒、大量吸烟及长期服用非甾体类药物。

Objective To analyze the clinical epidemiology of reflux esophagitis（RE） in Nanyang city.Methods The information,such as the prevalence,age composition,infection rate of Helicobacter pylori（HP） and other risk factors of 488 patients with RE diagnosed by endoscopy from July 2007 to December 2009 were analyzed,and compared with other digestive tract diseases.Results The incidence of RE was 4%.The ratio between male and female was 5.1 to 1.It was predominant in the middle age people.The average age was 45 years old.The infection rate of HP（21.1%） in RE was remarkably lower than the infection rate（45.02%,P＆lt;0.01） of other digestive tract diseases at the same term.RE was accompanied mainly with duodenal ulcer and atrophic gastritis.The common risk factors of this area were heavy drinking,smoking and long-term non-steroidal drugs.According to the Los Angeles standards,Endoscopic reverse flow esophagitis graded mainly about A.B.（infection rate 90.9%）.Conclusion The RE was mild in degree.Middle-aged and elderly male are high-risk groups.The infection rate of HP is low in RE patients.RE was accompanied mainly with duodenal ulcer and hiatus hernia.The high-risk factors of the main symptoms are heavy drinking,smoking and long-term non-steroidal drugs.