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游离脂肪酸诱导胰岛β细胞损伤的分子机制 被引量:2

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摘要 2001年,Banting奖得主McGarry教授在美国糖尿病学会(ADA)年会上作了题为"在2型糖尿病发病中的脂肪酸代谢异常"的报告,指出脂代谢异常为2型糖尿病(T2DM)的原发性病理生理事件,同时基于脂代谢紊乱常先于糖尿病发病前数年存在这一事实,将T2DM称作“糖脂病”(Diabetes
出处 《中华全科医学》 2012年第1期86-87,153,共3页 Chinese Journal of General Practice
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  • 2Srinivasan M,Choi CS,Ghoshal P,et al.β-Cell-specific pyruvate de-hydrogenase deficiency impairs glucose-stimulated insulin secretion[J].Am J Physiol Endocrinol Metab,2010,299(6):E910-917.
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  • 7Zhang Y,Xiao M,Niu G,et al.Mechanisms of oleic acid deteriorationin insulin secretion:role in the pathogenesis of type 2 diabetes[J].Life Sci,2005,77(17):2071-2081.
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