瘅痛酊联合血塞通治疗糖尿病周围神经病变疗效观察

Efficacy Observation of Dantong Tincture and Xuesaitong in Treatment of Diabetic Peripheral Neuropathy

目的研究瘅痛酊联合血塞通治疗糖尿病周围神经病变的临床疗效,探讨糖尿病周围神经病变的有效治疗方法。方法将符合诊断标准的60例患者随机分为治疗组(30例)、对照组(30例)。对照组给予甲钴胺静脉滴注,并口服维生素B1;治疗组在对照组西药治疗基础上给予静脉滴注注射用血塞通400 mg、外擦瘅痛酊。观察两组治疗前后症状和神经传导速度的变化。结果治疗后,两组之间血糖含量比较,差异无统计学意义(P>0.05);治疗后神经传导速度组内比较,差异均有统计学意义(P<0.05或P<0.01),治疗后组间比较,P<0.05;治疗组和对照组总有效率分别为86.7%、66.7%,两组比较,差异有统计学意义(P<0.05)。结论瘅痛酊联合血塞通能改善糖尿病周围神经病变的微循环及神经传导速度,对糖尿病周围神经病变的治疗是有效的。

Objective To study the clinical efficacy on diabetic peripheral neuropathy （DPN）treated with dantong tincture and xuesaitong and explore the effective approach for the treatment of DPN. Methods 60 cases complied with the diagnostic standard were divided randomly into a treatment group （30 cases） and a control group（30 cases）. In treatment group, mecobalamin was applied to intravenous infusion and vitamin Bl was prescribed for oral administration. In treatment group, on the basis of the program as control group, the intravenous infusion of xuesaitong 400rag and external application of dantong tincture were applied. The symptoms and nerve conduction velocity（NCV） were observed before arid after treatment in two groups. Re- suits After treatment, the comparison of blood glucose level between two groups did not present statistical significance （P 〉 0.05 ）. In treatment group, NCV was accelerated apparently as compared with control group,indicating statistical significance（P 〈 0.05 or P 〈 0.01 ）. The effective rates were 86.7% and 66.7% in treatment group and control group respectively （P 〈 0.05 ）. Conclusion The combined therapy of dantong tincture and xuesaitong improves the microcirculation of DPN and NCV and is effective in the treatment of DPN.