胃癌患者凝血指标变化及临床意义

Changes and clinical significance of coagulation markers in patients with gastric cancer

目的探讨胃癌患者凝血功能指标检测的变化及临床意义。方法采用CA7000全自动血凝分析仪测定128例胃癌患者的凝血酶原时间(PT)、部分凝血活酶时间(APTT)、纤维蛋白原(Fib)、凝血酶时间(TT)、D-二聚体(D-D)和抗凝血酶-Ⅲ(AT-Ⅲ),并与67例胃溃疡患者、84例胃炎患者及65例健康体检者进行比较。结果胃癌患者PT、APTT、TT较胃溃疡、胃炎患者和健康人明显延长(P<0.05),Fib、D-D明显增高(P<0.05),AT-Ⅲ则明显减低(P<0.05)。结论 PT、APTT、TT′结果延长,提示胃癌患者存在凝血功能紊乱;Fib、D-D结果增高可致胃癌患者血栓形成和癌细胞远处转移。因此,凝血功能指标监测对胃癌患者的治疗具有一定的指导意义。

Objective To explore the change and clinical significance of the coagulation function indexes in gastric cancer patients.Methods Using CA7000 fully-automatic blood coagulation analyzer,the prothrombin time（PT）,activated partial thromboplastin time（APTT）,thrombin time（TT）,fibrinogen（Fib）,D-dimer（D-D） and antithrombase-Ⅲ（AT-Ⅲ） were determined in 128 patients with gastric cancer,67 patients with peptic ulcer,84 patients with gastritis and 65 normal controls.Results PT,APTT and TT in the gastric cancer patients group were obviously extended than those in normal group（P0.05）.And Fib and D-D were significantly higher than those in the normal group（P0.05）.However,AT-Ⅲwas remarkably lower than that in the normal group（P0.05）.Conclusion Prolongation of PT,APTT and TT reveals the disorder of coagulation function in the patients with gastric cancer.Fib and D-D increase could lead to thrombosis and distal metastasis of cancer cells.Therefore,monitoring the coagulation indexes has certain guidance significance to treatment of gastric cancer.