下呼吸道感染的菌群分布及耐药性分析

Bacterial flora distribution and drug resistance analysis of lower respiratory tract infections

目的分析下呼吸道感染后的菌群分布及细菌对抗生素耐药情况,为临床合理使用抗生素提供科学依据。方法对下呼吸道感染患者进行菌群分布及细菌对抗生素耐药情况分析。结果共检测到422株致病菌,菌群分布:铜绿假单胞菌、大肠埃希菌、肺炎克雷伯菌、副流感嗜血杆菌、鲍曼不动杆菌为5种主要致病菌。对5种抗菌药物较敏感:左氧氟沙星、阿米卡星、环丙沙星、头孢哌酮、亚胺培南;对5种抗菌药物较耐药:氨苄西林、苯唑西林、哌拉西林、头孢他啶、头孢唑林。结论引起该院下呼吸道感染的病原菌主要为革兰阴性杆菌,其耐药情况可为临床抗菌药物合理应用提供参考。

Objective To investigate the bacterial flora distribution and drug resistance in lower respiratory tract infections and to provide the scientific evidence for clinical rational antibiotics use.Methods To analyze the bacterial flora distribution and drug resistance in the patients with lower respiratory tract infections.Results 422 strains of pathogens were isolated.The bacterial flora distribution included 5 species of main pathogenic bacteria Pseudomonas aeruginosa,Escherichia coli,Klebsiella pneumoniae,Haemophilus parainfluenzae and Acinetobacter baumannii.They showed the sensitivity to 5 kinds of antimicrobials L-ofloxacin,amikacin,ciprofloxacin,cefoperazone,cefoperazone and imipenem and the tolerance to ampicil,oxacillin,piperacillin,ceftazidime and cefazolin.Conclusion The main pathogenic bacteria of lower respiratory tract infections in our hospital are Gram-negative bacilli.Their drug resistance status provides the scientific reference for clinical rational antimicrobials use.