4(5)-氰基咪唑的合成与表征

Synthesis and Characterization of 1H-Imidazole-4-Carbonitrile

以D-果糖为初始原料,经环合、氧化,再加入盐酸羟胺作为氰基化试剂一步法制得4(5)-氰基咪唑。利用~1H NMR、^(13)C NMR等手段对各步所得产物的结构进行了表征,结果表明产物为4(5)-氰基咪唑。以D-果糖计,3步反应的总收率为33.5%。

~1H-Imidazole-4-carbonitrile were synthesized with D-fructose as starting materials by cyclization,oxidation and cyanation in a one-spet process by adding hydroxylamine hydrochloride.The structure of the compound was confirmed by ~1H NMR,^（13）C NMR etc.The target product was identified as ~1H-imidazole-4-carbonitrile.The overall yield of fructose was 33.5%in three steps.