雷公藤胃漂浮缓释胶囊的制备及体外释放度的考察

Preparation of Tripterygium wilfordii Hook.f.Gastric Floating Sustained-Release Capsule and Its Drug Release

制备了雷公藤胃漂浮缓释胶囊,对其释放机制进行考察。建立HPLC法考察其体外释放度,以羟丙基甲基纤维素（HPMC_（K4M））为主要辅料,制备亲水凝胶型骨架胶囊,采用L_g（3~4）正交试验筛选出胶囊的处方。所制备的胃漂浮缓释胶囊在12h内呈良好的零级释药特征;以正交试验设计的雷公藤胃漂浮缓释胶囊处方合理,体外释放性能良好。

The Tripterygium wilfordii Hook.f.gastric floating sustained-release capsule was prepared,and its release mechanism was investigated,and study on it in vitro drug release by HPLC was established,then water-affinity-gel type skeleton capsule was prepared with hydroxypropyl methyl cellulose（HPMC_（K4M）） as main auxiliary material,and the prescription of capsule was screened out by L_9（3~4） orthogonal test.The prepared gastric floating sustained-release capsule had the good zero-level of drug release features within 12h.There is reasonable that prescription Tripterygium wilfordii Hook.f.gastric floating sustained-release capsule was designed by orthogonal test with good performance in vitro drug release.