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白介素-16基因多态性与广西地区鼻咽癌遗传易感性的研究 被引量：3

Association between polymorphisms of interleukin-16 gene and susceptibility to nasopharyngeal carcinoma in Guangxi
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摘要 目的研究广西地区人群白介素-16(IL-16)基因多态性与鼻咽癌(NPC)遗传易感的相关性。方法对来自广西地区的75例鼻咽癌患者和75例健康体检者采用聚合酶链反应-限制性片段长度多态性(PCR-RFLP)及酶联免疫吸附法,分析IL-16基因的3个单核苷酸多态性(SNP)位点(rs11556218T/G、rs4778889T/C、rs4072111C/T)多态性与NPC的相关性。结果 IL-16基因rs11556218位点在NPC患者中TG基因型分布频率(49.3%)显著高于健康对照组(34.7%)(P=0.037)。NPC组IL-16-rs11556218G等位基因频率为32.7%,高于正常对照组的21.3%(P=0.027),并且G等位基因携带者的血清IL-16水平明显高于TT基因型(P=0.00)。携带GTT和GCC单倍型的个体罹患鼻咽癌风险性是携带TTC单倍型者的2.95倍和2.73倍。结论 IL-16基因rs11556218位点的基因多态性与广西地区鼻咽癌的遗传易感性有关,TG基因型可能是NPC发生的易感基因型,携带G等位基因的个体患NPC风险增高。 Objective To investigate the association of polymorphisms of interleukin 16 with susceptibility to nasopharyngeal carcinoma in Guangxi population,South-east China. Methods The genotype and allele of IL-16 SNPs rsl 1556218T/G,rs4778889T/ C,rs4072111C/T were identified by PCR RFLP and sequencing,in 75 NPC patients and 75 heahhy subjects in Guangxi. Results IL 16-rs11556218 TG genotype distribution frequency was significantly higher in NPC patients＇ （49. 3G） than the control group （34.7%） （P=0. 037）. Its G allele frequency was 32. 7% in NPC group, significantly higher than the control group, which was 21.3%（OR=1. 79;95% CI：1.01-3.00;P=0. 027）. And the G allele of IL-16 serum levels were significantly higher than the TT genotype （P=0.00）. Compared with the TTC haplotype,the risk of suffering nasopharyngeal cancer was 2.95 fold ,and 2.73 fold respectively in the GCC and GTT haplotype individuals. Conclusion IL-16 rs11556218 gene polymorphisms are associate with ge netic susceptibility of nasopharyngeal carcinoma in Guangxi region,China. TG genotype may be susceptible to NPC,individuals ear rying the G allele increased the risk of suffering from NPC.
作者 黄珊 劳小霞 秦雪 李山
机构地区 广西医科大学研究生学院 广西民族医院检验科 广西医科大学第一附属医院临床医学实验部 广西医科大学医学检验系
出处 《重庆医学》 CAS CSCD 北大核心 2012年第3期220-223,226,共5页 Chongqing medicine
关键词 白介素-16 多态性 单核苷酸 鼻咽肿瘤 单倍型 聚合酶链反应-限制性片段长度多态性 interleukin-16 polymorphism, single nucleotide nasopharyngeal neoplasms haplotype PCR-RELP
分类号 R739.63 [医药卫生—肿瘤]
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参考文献15

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共引文献6

同被引文献33

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重庆医学
2012年 第3期

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