VEGF受体Ⅱ在胃癌组织中表达及临床意义

Expression and clinical significance of vascular endothelial growth factor receptorⅡ(KDR) in gastric carcinoma

目的探讨胃癌组织中血管内皮生长因子受体Ⅱ(VEGFR2,KDR)的表达及其临床意义。方法应用免疫组织化学方法检测34例胃癌组织和10例正常胃组织中的KDR表达。结果胃癌组织中KDR的表达量升高。KDR表达量与淋巴结转移、病理分期、肿瘤分化程度密切相关(P<0.05),与患者的性别、年龄无关(P>0.05)。结论 KDR在胃癌的发生、发展中起重要作用,这为胃癌的靶向治疗提供了有力依据。

Objective To study the expression and clinical role of vascular endothelial growth factor receptorⅡ（VEGFR2,KDR） in gastric carcinoma. Methods The expression of KDR was detected with immunohistochemistry in 34 cases of gastric cancer（group A） and 10 cases of healthy gastric tissues. Results The high expression of KDR was seen in group A,which was correlated with the lymph node metastasis,TNM stages and differentiation degrees of the tumor（P0.05）,but not correlated with the sex and age of the patients（P0.05）. Conclusion KDR plays an important role in the carcinogenesis and progression of gastric cancer,which may provide a basis for the target molecular therapy of gastric cancer.