地衣芽胞杆菌治疗肝硬化并自发性细菌性腹膜炎的临床疗效研究

Clinical efficacy of Bacillus licheniformis in treatment of spontaneous bacterial peritonitis in patients with liver cirrhosis

目的观察益生菌治疗肝硬化自发性细菌性腹膜炎(SBP)患者的效果。方法将60例肝硬化自发性细菌性腹膜炎随机分成2组,对照组30例,予抗感染、保肝、降门脉高压、利尿、营养支持治疗;治疗组30例,在对照组的综合治疗基础上加用地衣芽胞杆菌胶囊,每日3次,每次2粒,连服21 d后观察感染控制及肝功能变化情况。结果治疗组总有效率明显高于对照组,除了腹痛、腹部压痛无差异外,发热、腹泻消失、腹水常规、肝功能改善方面与对照组比较差异存在统计学意义(P<0.05)。结论益生菌对肝硬化并发自发性腹膜炎有一定治疗效果。

Objective To observe the effect of probiotics on Spontaneous Bacterial Peritonitis （SBP） in patients with Liver Cirrhosis. Method Sixty SBP patients were divided into two groups. The 30 patients in the control group were given treatments of anti-infection, liver-protection, lower portable hypertention, diuresis and nutritional support, while the 30 patients in the treatment group were given the same therapy plus an additional Zhengchangsheng capsule for 21 days. The variations in infection control and Hepatic function were compared between two groups. Result There were significant differences （ P 〈 0.05 ） between two groups with regards to the disappear of fever and diarrhea, ascites analysis and improvement of hepatic function. Conclusion Probiotics has a certain therapeutic effect to SBP in liver cirrhosis.