奥曲肽联合奥美拉唑治疗肝硬化并上消化道出血的临床研究

Clinical Study on Combination of Octreotide and Omeprazole in Treatment of Liver Cirrhosis with Upper Gastrointestinal Hemorrhage

目的探讨奥曲肽与奥美拉唑联合治疗肝硬化合并上消化道出血的临床疗效。方法选取我院2010年7月至2011年7月期间收治的肝硬化合并上消化道出血患者86例,随机将患者分为研究组43例和对照组43例。两组患者经明确诊断后均予一般常规治疗,研究组在常规治疗的基础之上给予奥曲肽与奥美拉唑的药物联合治疗,而对照组则仅给予垂体后叶素的药物治疗,并对两组患者的临床治疗情况及不良反应发生情况进行比较分析。结果研究组与对照组相比,患者显效率和总有效率的上升趋势以及无效率的下降趋势均较为显著,差别均具有统计学意义(P<0.05);患者的平均止血时间、平均住院时间均明显缩短,且48h再出血率显著降低,差别均具有统计学意义(P<0.05);患者不良反应发生率显著降低,差别具有统计学意义(P<0.05)。结论奥曲肽联合奥美拉唑治疗肝硬化合并上消化道出血,其临床治疗效果较为显著,且不良反应发生率低,对于肝硬化合并上消化道出血患者的临床治疗具有极其重要的意义。

Objective To explore the clinical effect ofoetreofide combined with omeprazole in the treatment of upper gastrointestinal hemorrhage in liver cirrhosis. Methods 86 cases of liver cirrhosis patients with upper gastrointestinal hemorrhage in our hospital from July 2010 to July 2011 were divided into observation group （43 cases） and control group （43 cases）. All diagnosed patients received conventional treatment, based on which the observation group was treated with octreotide and omeprazole extra, while the control group was treated with pituitrin. The clinical effect and adverse reaction of two groups were compared and analysed. Results Compared with the control group, the observation group had a prominent uptrend in efficiency and downtrend in inefficiency, and differences were significant （P 〈0.05）; The average hemostatic time and hospital stay time were significantly shortened, and the rebleeding rate after 48 h was significantly reduced, and differences were significant （P〈0.05）; The incidence rate of adverse reaction reduced signally, and the difference was significant （P〈0.05）. Conclusion Oetreofide combined with omeprazole in the treatment of upper gastrointestinal hemorrhage in liver cirrhosis has remarkable efficacy and lower incidence rate of adverse reactions, which has an important clinical significance.