真菌菌血症相关危险因素及药敏试验分析

Risk factors for fungal bacteremia and drug susceptibility

目的总结10年真菌菌血症流行病学、病原谱及药敏特点,为真菌菌血症防治提供依据。方法回顾性调查分析1998-2007年医院发生的75例真菌菌血症。结果共分离出91株病原菌,主要为白色假丝酵母菌、光滑假丝酵母菌;广谱抗菌药物的使用率为93.3%,白色假丝酵母菌与非白色假丝酵母菌组间相关因素比较差异无统计学意义,氟康唑对白色假丝酵母菌的敏感率为98.1%,对光滑假丝酵母菌的敏感率达到86.4%。结论广谱抗菌药物的应用,可能是真菌菌血症的最常见的危险因素,氟康唑对于白色假丝酵母菌和光滑假丝酵母菌仍有较高的敏感率。

OBJECTIVE To study the epidemiology,the disease spectrum of fungal bacteriemia,and the characteristics of drug susceptibility during the past ten years in order to provide evidence for the prevention and control.METHODS A total of 75 cases of fungal bacteriemia occurred from 1998 to 2007 in our hospital were reviewed retrospectively.RESULTS Totally 91 strains of pathogens were isolated,which were mainly Candida albicans and C.glabrata.The application rate of broad spectrum antibiotic was 93.3%.The susceptibility rate of C.albicans to fluconazole was 98.1%,compared with C.glabrata 86.4%.CONCLUSION The application of broad spectrum antibiotic may be the most common risk factor for the fungal bacteriemia,C.albicans and C.glabrata remain highly susceptible to fluconazole.