小儿下呼吸道感染常见病原菌分布及耐药性分析

Distribution and drug resistance of common pathogens causing lower respiratory tract infection in children

目的了解小儿急性下呼吸道感染常见病原菌分布及对抗菌药物的耐药性,为临床合理用药提供依据。方法对2007年1月-2009年12月儿科送检的下呼吸道标本所分离的病原菌,进行菌种分布和耐药性回顾性统计分析。结果从送检的标本中检出病原菌945株,其中革兰阴性杆菌566株,占59.89%,革兰阳性球菌238株,占25.19%,真菌141株,占14.92%;亚胺培南、头孢哌酮/舒巴坦对革兰阴性杆菌最敏感,万古霉素、替考拉宁对阳性球菌最敏感。结论下呼吸道感染病原菌以革兰阴性杆菌为主,临床应合理应用抗菌药物,减少耐药性的产生。

OBJECTIVE To investigate the distribution and antibiotic resistance of pathogens isolated from sputum of children with lower respiratory tract infection for rational antibiotics therapy.METHODS A retrospective analysis for the distribution and antibiotic resistance of pathogens isolated from sputum of children with lower respiratory tract infection was made from Jan 2007 to Dec 2009.RESULTS Totally 945 strains were isolated,of which there were 566 strains of gram-negative bacilli,accounting for 59.89%,238 strains of gram-positive cocci,accounting for 25.19% and 141 strains of fungi,accounting for 14.92%.Imipenem and cefoperazone/sulbactam were most sensitive against gram-negative bacilli,while vancomycin and teicoplanin were most sensitive against gram-positive cocci.CONCLUSION gram-negative bacilli are the major pathogens in children with lower respiratory tract infection.Antibiotic resistance becomes more prevalent in some major pathogens.Rational use of antibiotics is important to reduce bacterial resistance.