儿童血培养中凝固酶阴性葡萄球菌的耐药性分析

Drug resistance of children blood culture-derived coagulase-negative Staphylococcus

目的了解儿童凝固酶阴性葡萄球菌(CNS)的感染及耐药性。方法收集2008-2010年血培养分离的2522株凝固酶阴性葡萄球菌,药敏试验采用纸片扩散法(K-B法)。结果 2522株凝固酶阴性葡萄球菌中表皮葡萄球菌1161株,占46.03%,溶血葡萄球菌811株,占32.16%,人葡萄球菌284株,占11.26%;凝固酶阴性葡萄球菌对抗菌药物的耐药率分别是苯唑西林为78.31%、磺胺甲噁唑/甲氧苄啶为51.03%、克林霉素为33.31%、利福平为3.37%、利奈唑胺为0.16%、青霉素为93.97%、替考拉宁为0.48%、万古霉素为0。结论耐甲氧西林凝固酶阴性葡萄球菌已成为儿童血液感染的主要病原菌。

OBJECTIVE To investigate coagulase-negative Staphylococci（CNS） infections in children and its drug resistance.METHODS A total of 2522 strains of coagulase-negative Staphylococci were collected from blood culture for children hospitalized in Wuhan children＇s hospital from 2008 to 2010.The drug susceptibility to antibiotics was determined by disk diffusion method（KB method）.RESULTS Of 2522 strains of coagulase-negative Staphylococci,1161（46.03%）strains were S.epidermidis,811（32.16%） strains were S.haemolyticus,and 284（11.26%） strains were S.homis;the resistance rates to oxacillin,cotrimoxazole,clindamycin,rifampin,linezolid,penicillin,teicoplanin,and vancomycin were 78.31%,51.03%,33.31% 3.37%,0.16%,93.97%,0.48%,and 0,respectively.CONCLUSION Methicillin-resistant coagulase-negative Staphylococci（MRCNS） have become the major pathogens causing blood infections in children.