新生儿滴虫性肺炎的临床分析

Clinical analysis of neonatal trichomonal pneumonia

目的探讨新生儿滴虫性肺炎的病原学特点、临床特征和甲硝唑治疗的有效性。方法对2000年5月至2009年11月本院新生儿病房收治的新生儿滴虫性肺炎病例进行回顾性分析,总结其临床特点、病原种类、影响因素、治疗和预后。结果共诊断34例滴虫感染新生儿肺炎,其中9例为重症肺炎;胎龄、分娩方式、出生时有无窒息、出生体重及母孕期有无妊娠合并症与肺炎严重程度无相关性(P>0.05);疗效与甲硝唑治疗起始时间、肺炎严重程度无相关性。结论滴虫是引起新生儿肺炎的病原学之一,如果临床常规抗感染治疗效果不佳,应考虑滴虫感染并采取针对性治疗。

Objective To explore the etiology and the clinical features of neonatal trichomonal pneumonia, and its response to metronidazole therapy. Methods Between 2000 May to 2009 Nov neonates diagnosed trichomonal pneumonia were included for further analysis of their clinical characteristics, etiology, influential factors, treatment and prognosis. Results Thirty-four neonates were found, including 9 cases with severe pneumonia. Gestational age, mode of delivery, history of asphyxia, birth weight and maternal pregnancy complication were not related to pneumonia severity （ P 〉 0. 05 ）. There was no relation to the timing of initiation of metronidazole treatment and pneumonia severity. Conclusions Trichomonas was one of the etiology of neonatal pneumonia. If antibiotic therapy was not effective, trichomonas infection should be considered.