鼻内翻性乳头状瘤组织中COX-2的表达及临床意义

Expression and Significance of COX-2 in Nasal Inverted Papilloma

目的探讨COX-2蛋白在鼻内翻性乳头状瘤(NIP)组织中的表达及在该病恶变中的临床意义。方法采用免疫组织化学SABC法检测72例NIP组织中COX-2蛋白的表达水平,利用图像分析技术测量阳性细胞的平均光密度值(AOD),并取10例下鼻甲组织做对照。结果 NIP组织中AOD高于正常鼻黏膜,差异有统计学意义(P<0.05);NIP组织中COX-2的表达与患者的年龄、性别无关(P>0.05),与吸烟、Krouse分期有关(P<0.05)。结论 COX-2与NIP的发生及其恶变有一定相关性,抑制COX-2活性及戒烟对预防NIP的发生及恶变有一定的临床价值。

Objective To detect the expression of COX-2 protein in nasal inverted papilloma （NIP） and investigate their clinicopathological significances in occurrence and aggravation of this disease. Methods 10 cases of inferior turbinate tissues （IT）, 60 cases of NIP without malignant transformation, 12 cases of NIP with malignant transformation were examined for COX-2 expression by Immunohistochemistry. Results The expression of COX-2 in NIP with malignant transformation was significantly higher than that of NIP without malignant transformation and in IT （P 〈 0.05 ）,meanwhile there had significant differences between NIP without malignant transformation and IT （P 〉 0.05 ）.Besides,the expression of COX-2 protein had no correlation with age and gender（P 〉 0.05）, but a correlation with smoking was detected（P 〈 0.05）. Conclusion The abnormal expression of COX-2 protein might play an important role in occurrence and aggravation of NIP,it would be valuable of inhibition the COX-2 activity and smoking cessation for prevention and aggravation of NIP.